Efficacy Evaluation of The Melissa Officinalis Syrup in Treatment of Children's Anxiety Symptoms with Attention Deficit Hyperactivity Disorder

Background

ADHD is a prevalent neuropsychiatric condition and often accompanied by anxiety disorders. This comorbidity exacerbates ADHD symptoms, impairs academic and social functioning. Melissa officinalis (lemon balm), a traditional herbal remedy with anxiolytic properties, has shown promise in reducing anxiety but remains underexplored in children with ADHD. This study aims to assess the efficacy of Melissa officinalis syrup in reducing anxiety symptoms in children aged 7 to 12 years diagnosed with ADHD and mild to moderate anxiety.

Methods

This double-blind, randomized controlled trial enrolled 30 children aged 7 to 12 years with ADHD and mild to moderate anxiety. Participants were randomly assigned to receive either Melissa officinalis syrup (0.2 ml/kg/day, divided into two doses) or a placebo syrup for 6 weeks, alongside their standard ADHD medication. Anxiety and ADHD symptoms were assessed at baseline, week 3, and week 6 using the RCMAS and ADHD Rating Scale.

Results

The Melissa officinalis group showed a significant reduction in anxiety symptoms by week 6 (RCMAS score reduction: 41.5%) compared to the placebo group (10.4%). No significant difference in anxiety scores was observed at week 3. ADHD symptoms also improved significantly in the Melissa officinalis group at week 3 and week 6. No adverse events were reported in either group.

Conclusion

Melissa officinalis syrup is an effective adjunctive treatment for reducing anxiety and improving ADHD symptoms in children with ADHD over 6 weeks, with a favorable safety profile. These findings suggest its potential as a complementary therapy, particularly given the limitations of existing treatments.