Kleine-Levin Syndrome in a young woman: A case report

نوع مقاله : گزارش مورد


1 Resident of psychiatry, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Assistant professor of psychiatry, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


Introduction: Klein-Levin Syndrome (KLS) is a rare disorder identified by recurrent hypersomnia, over-eating, or hypersexuality and is associated with cognitive dysfunction or abnormal behaviors.
 Case presentation: In this paper, we presented a 36-year-old single female with chief complaints of headaches, tiredness, and sleepiness. She reported attacks of hypersomnia and memory deficits from childhood. She experienced addiction to alcohol, caffeine, and sugar, also depression, and suicidal taught. The full medical work-up did not indicate any organic illness. Polysomnography and Multiple Sleep Latency Tests indicated narcolepsy. Finally, she was diagnosed with Klein-Levin syndrome.
 Conclusion: Kleine-Levin Syndrome is a challenging diagnosis. The medical history of clinical symptoms and exclusion of other diagnoses can lead to better diagnosis in patients with hypersomnolence.


  1. Tuzim K, Tuzim T, Urbańczuk M, Urbańczuk M, Schab K. Kleine-Levin Syndorme: aetiology and pathogenesis, symptoms, diagnosis and treatment. Journal of education, health and sport 2018; 8(8): 658-66.
  2. Ortiz JF, Argudo JM, Yépez M, Moncayo JA, Tamton H, Aguirre AS, et al. Neuroimaging in the rare sleep disorder of Kleine-Levin Syndrome: A systematic review. Clocks Sleep 2022; 4: 287-99.
  3. Shah F, Gupta V. Kleine–Levin syndrome (KLS). In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2021. Available from: https://europepmc.org/article/nbk/nbk568756
  4. Arnulf I, Groos E, Dodet P. Kleine-Levin syndrome: A neuropsychiatric disorder. Rev Neurol 2018; 174(4): 216-27.
  5. Miglis MG, Guilleminault C. Kleine-Levin syndrome: A review. Nat Sci Sleep 2014; 6: 19-26.
  6. BaHammam AS, GadElRab MO, Owais SM, Alswat K, Hamam KD. Clinical characteristics and HLA typing of a family with Kleine-Levin syndrome. Sleep Med 2008; 9: 575-8.
  7. Naresh N, Navratan S. Sleeping beauty syndrome: a case report and review of female cases reported from India. Indian J Psychol Med 2017; 39(3): 357-60.
  8. Billiard M, Jaussent I, Dauvilliers Y, Besset A. Recurrent hypersomnia: A review of 339 cases. Sleep Med Rev 2011; 15(4): 247-57.
  9. AlShareef SM, Smith RM, BaHammam AS. Kleine-Levin syndrome: clues to aetiology. Sleep Breath 2018; 22(3): 613-23.
  10. Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: A systematic review of 186 cases in the literature. Brain 2005; 128(Pt 12): 2763-76.
  11. Assi B, Yapo-Ehounoud C, Baby MB, Aka-Diarra E, Amon-Tanoh M, Tanoh C. The Kleine-Levin Syndrome: A rare disease with often delayed diagnosis-A report of two cases in the Department of Neurology of the University Hospital of Cocody (Côte d'Ivoire). Case Rep Neurol Med 2016; 2016: 8929413.
  12. Olufunke Afolabi-Brown, Thornton BA Mason II. Paediatr Respir Rev 2018; 25: 9-13.
  13. Shukla GD, Bajpai HS, Mishra DN. Kleine-levin syndrome: A case report from India. Br J Psychiatry 1982; 141: 97-8.
  14. Huang YS, Lin YH, Guilleminault C. Polysomnography in Kleine-Levin syndrome. Neurology 2008; 70(10): 795-801.
  15. Kas A, Lavault S, Habert MO, Arnulf I. Feeling unreal: A functional imaging study in patients with Kleine-Levin syndrome. Brain 2014; 137(Pt 7): 2077-87.
  16. Yildirim G, Ekinci AS. Kleine-Levin Syndrome: Two cases. Turk J Neurol 2021; 27: 426-9.
  17. Alemohammad ZB, Jamshidi S, Najafi A. Periodic hypersomnolence in a young female patient: a case report and literature review. Egypt J Neurol Psychiatry Neurosurg 2022; 58: 33.