Comparison of brain behavioral systems between methamphetamine dependent and normal people; based on Gray’s revised reinforcement sensitivity theory

Document Type : Research Paper



Introduction: The aim of this study was to compare three systems of revised reinforcement sensitivity theory, behavioral activation system (r-BAS), revised behavioral inhibition system (r-BIS) and revised fight/flight/freezing system (r-FFFS), between patients who are dependent to methamphetamine and normal people.
Materials and Methods: This research was a causal-comparative study that was done in the first sex month of 2012 in Mashhad. The population of the study were men dependent on methamphetamine without psychotic disorders and prominent axis II comorbidities. Twenty five individuals were selected by convenient sampling method. Also 25 normal people from patients’ relatives were selected and matched in variables of age, gender and education participated in this study. Samples were evaluated by Structured Clinical Interview (SCID) for DSM-IV, demographic questionnaire information's and Jackson-5 questionnaire. Data were analyzed by Chi square, Kolmogrov-Smirnov and independent t-test.
Results: Methamphetamine dependent group had higher sensitivity in r-BAS, r-BIS, fight and freezing systems compare to normal people (P<0.05). However there was no significant difference in r-flight between two groups (P>0.05).
 Conclusion: Personality patterns of patients dependent on methamphetamine were different from normal people. This people have high sensitivity to punishment cues such as being compared in social conditions and tendency to reinforcement and reward, because of their higher sensitivity in behavioral inhibition and activation system.


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