Heat Shock Protein 27 (HSP27) Antibody and amphetamine and other substance abuse: A review study

Document Type : Review Article


Psychiatrist, Tabas, Iran


Introduction: Heat Shock Protein (HSP) expression is observed in central nerve system at different stressful condition like hypothermia, hypoxia, trauma, status epilepticus, and drug abuse. Also, HSP is suggested as a molecular protection for cellular damaged proteins. The aim of this review was to evaluate and summarize the studies about the role of HSP in psychotic caused by substance abuse.
 Materials and Methods: In this review article, all the articles published up to December 2014 in both Persian and English language about the relationship between heat shock protein and drug abuse had been evaluated. These studies were searched in database of SID, IranMedex, IranDoc, Margiran, Science Direct, Ovid, Google Scholar, PubMed, CINAHL and using key words of HSP27 AND drug abuse. The used keywords were selected based on MeSH Database. To collect data, Data Extraction Form was used that it was designed based on the objective of the study. The result of this search was to obtain 11 related articles that 5 articles were excluded due to lack of inclusion criteria and ultimately 6 articles entered to the study.
 Results: The oldest performed study was related to 2001 and the most recent was in 2014. 3 studies (50%) were performed on rat and 3 (50%) on mice. 4 articles was about morphine abuse, 1 about amphetamine abuse, and 1 about phenobarbital.
 Conclusion: All the researches showed that HSP27 increases after substance withdrawal, and it seems that it has damage protective effect.