Evaluating the effect of transcranial light therapy on depression symptoms and quantitative electroencephalographic changes

Document Type : Research Paper

Authors

1 Department of Psychology, Payam Noor University, Tehran, Iran

2 Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction: The present study aimed to evaluate the effect of transcranial light therapy on depression symptoms and quantitative electroencephalographic changes.
Materials and Methods: In this clinical trial, six cases with depression were selected through convenient method and randomly divided into two experimental and control groups. Beck Depression Inventory and Quantitative Electroencephalographic Changes (QEEG) were performed in pretest and post-test. The treatment performed in 10 sessions (twice a week for 3 or 4 minutes). The forehead and F3 and F4 sites selected for stimulation. Data analyzed through descriptive statistics, Mann-Whitney U test, Wilcoxon, T test, and SPSS software.
Results: Delta wave amplitudes showed a significant difference between two groups in FP2 channel (P= 0.016). The results of Beck Depression Inventory showed a significant decrease in experimental group (P=0.03).
Conclusion: Based on the results of the present study, low-level light therapy can be considered as a promising treatment and an effective, affordable and low-cost method for depression disorder and cognitive function.

Keywords


  1. Morin A. Depression statistics everyone should know. [cited 2018]. Available from://www.verywellmind.com.
  2. Hamblin M, Demidova TN. Mechanisms of low level light therapy. Proceedings of SPIE - The International Society for Optical Engineering, 2014; 6140: 1-12.
  3. Schiffer F, Johnston AL, Ravichandran C, Polcari A, Teicher MH, Webb RH, et al. Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behav Brain Funct 2009; 5: 46.
  4. Gustavo Rocha Peixoto dos Santos J, Luiza Costa Zaninotto A, Amaro Zângaro R, Costa Carneiro AM, Santana Neville L, Ferreira de Andrade A, et al. Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe acute traumatic brain injury: study protocol for a randomized controlled trial. Trials 2018; 19: 249.
  5. Tuchin VV. Handbook of photonics for biomedical science. Florida: CRC press; 2010.
  6. Naeser MA, Zafonte R, Krengel MH, Martin PL, Frazier J, Hamblin MR, et al. Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: Open-protocol study. J Neurotrauma 2014; 31(11): 1008-17.
  7. Naeser MA, Saltmarche A, Krengel MH, Hamblin MR, Knight JA. Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports. Photomed Laser Surg 2011; 29(5): 351-8.
  8. Cassano P, Petrie SR, Hamblin MR, Henderson TA, Iosifescu DV. Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis. Neurophotonics 2016; 3(3): 031404.
  9. Naeser MA, Hamblin MR. Potential for Transcranial Laser or LED Therapy to Treat Stroke, Traumatic Brain Injury, and Neurodegenerative Disease. Photomed Laser Surg 2011; 29(7): 443-6.

10 Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: Psychometric properties. J Consult Clin Psychol 1988; 56(6): 893-7.

  1. Azokhush M. [The application of psychological tests and clinical diagnosis]. 3rd ed. Tehran: Ravan; 2008: 226-4. (Persian)
  2. Schaffer M, Bonel H, Sroka R, Schaffer PM, Busch M, Reiser M, et al. Effects of 780 nm diode laser irradiation on blood microcirculation: preliminary findings on time-dependent T1-weighted contrast-enhanced magnetic resonance imaging (MRI). J Photochem Photobiol B 2000; 54(1): 55-60.
  3. Fahim C, Stip E, Mancini-Marie A, Mensour B, Leroux JM, Beaudoin G, et al. Abnormal prefrontal and anterior cingulate activation in major depressive disorder during episodic memory encoding of sad stimuli. Brain and cognition 2004; 54(2): 161-3.
  4. Mental health daily. Transcranial photobiomodulation for depression: Near-infrared light and laser therapy. [cited 2016]. Available from: http://mentalhealthdaily.com
  5. Schiffer F, Johnston AL, Ravichandran C, Polcari A, Teicher MH, Webb RH, et al. Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behav Brain Funct 2009; 5: 46.
  6. Barrett DW, Gonzalez-Lima F. Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. Neuroscience 2013; 230: 13-23.
  7. Disner SG, Beevers CG, Gonzalez-Lima F. Transcranial Laser Stimulation as neuroenhancement for attention bias modification in adults with elevated depression symptoms. Brain Stimul 2016; 9(5): 780-7.
  8. Gonzalez-Lima F. Dose-response effects of low-level light therapy on brain and muscle. Proceeding of the 13th Annual International Conference on Dose-Response. Texas: The University of Texas at Austin; 2014.
  9. Henderson TA, Morries LD. SPECT perfusion imaging demonstrates improvement of traumatic brain injury with transcranial near-infrared laser phototherapy. Adv Mind Body Med 2015; 29(4): 27-33.
  10. Morries LD, Cassano P, Henderson TA. Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy. Neuropsychiatr Dis Treat 2015; 11: 2159-75.
  11. Cassano P, Petrie SR, Mischoulon D, Cusin C, Katnani H, Yeung A, et al. Transcranial photobiomodulation for the treatment of major depressive disorder. The ELATED-2 pilot trial. Photomed Laser Surg 2018; 36(12): 634-46.
  12. Askalsky P, Iosifescu DV. Transcranial photobiomodulation for the management of depression: Current perspectives. Neuropsychiatr Dis Treat 2019; 15: 3255-72.