Introduction: Due to its basic role in the reproduction of the species, sexual relationship has always been a vital issue throughout the history, and it plays a major role in any happy and successful marital relationship. The aim of this study was to investigate the relationship between sexual satisfaction in working women in Mashhad Ferdowsi University and Shiraz University based on the maladaptive schemas.
 Materials and Methods:The statistical community of this ex-post research includeswomen working in Ferdowsi and Shiraz universities. Two questionnaires of early maladaptive schemas and marital satisfaction questionnaire were randomly given to 127 women working in Ferdowsi and Shiraz universities during May to July of 2014 and selected by simple random sampling through ex-post facto investigation. 95 participants met the inclusion criteria and consisted of women aged 28 to 41 years old. Research results analyses were conducted through multiple regression step models by SPSS software17.
 Results: According to the early maladaptive schemas, four schemas including emotional deprivation, mistrust, abandonment, and defectiveness have a significant role in the prediction of sexual satisfaction in women (P=0.001).
 Conclusion: Based on findings we can estimate that four schemas including emotional deprivation, mistrust, abandonment, and defectiveness in the disconnection and rejection domain have a significant relationship with sexual satisfaction and through any intervention on manipulating each factor, we can improve sexual satisfaction.