Fundamentals of Mental Health

Fundamentals of Mental Health

The effectiveness of mindfulness-based cognitive therapy in depression and serum cortisol levels in women with breast cancer and depressed women

Document Type : Research Paper

Authors
Zahra Olyaee 1
Masoud Mohammadi 2
Kazem Anvari 3
Seyed Ebrahim Hosseini 4
1 Ph.D. student, Department of Clinical Psychology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
2 Assistant professor, Department of Clinical of Psychology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
3 Professor, Department of Radiology, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Associate Professor Department of physiology, Shiraz Branch, Faculty of Science, Zand Institute of Higher Education, Shiraz, Iran.
10.22038/jfmh.2022.21513
Abstract
Introduction: This study aims to investigate the effectiveness of mindfulness-based cognitive therapy in depression and serum cortisol levels in women with breast cancer and depressed women.
 
Materials and Methods: In this clinical trial, 30 women with breast cancer who referred to Omid Hospital, Mashhad-Iran and 30 women with depression who referred to counseling clinics of Mashhad in 2020-2021 were selected by the convenience sampling method and were randomly assigned to four equal groups (2 experimental groups and 2 control groups). The experimental groups received mindfulness-based cognitive therapy during eight 90-120 minute sessions per week, while the control group did not receive any intervention. Research instruments included the Depression Inventory (BDI-II) and the blood samples to evaluate the cortisol levels. Data were analyzed through descriptive statistics, and the covariance analysis.
 
Results: The results of depressed people demonstrated that mindfulness-based cognitive therapy is effective to reduce depression and serum cortisol levels within the normal laboratory range (P< 0.001). Further, the findings of breast cancer women indicated that mindfulness-based cognitive therapy reduced depression and increased serum cortisol from low to moderate levels within the normal laboratory range (P< 0.001).
 
Conclusion: Mindfulness-based cognitive therapy can be effective in neurobiological mechanisms in addition to improving psychological symptoms in depressed individuals and cancer patients.
Keywords
Cancer
Cortisol
Depression
Mindfulness-based cognitive therapy
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Fundamentals of Mental Health
Volume 24, Issue 6
November and December 2022
Pages 419-426